keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 52,500 |
5 mg | 在庫あり | ¥ 156,000 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 383,500 |
50 mg | 在庫あり | ¥ 500,500 |
100 mg | 在庫あり | ¥ 643,000 |
説明 | Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors. |
ターゲット&IC50 | PLK1:3 nM, PLK2:149 nM, PLK3:393 nM |
In vitro | In KYSE-410 cells, Plogosertib (0, 0.07, 0.15, 0.3, 0.6, 1.25 μM; 72 hours) inhibits cell proliferation in a concentration-dependent manner[2]. |
In vivo | In the HL60 promyelocytic leukemia xenograft model, Plogosertib (40, 54, 67 mg/kg, qd 5/2/5; oral administration) inhibited tumor growth (>87%) without significant loss in body weight[2]. |
別名 | CYC140 |
分子量 | 616.797 |
分子式 | C34H48N8O3 |
CAS No. | 1137212-79-3 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Plogosertib 1137212-79-3 Cell Cycle/Checkpoint PLK AC010220.2HCl AC-010220 CYC-140 CYC 140 AC 010220 AC-220 AC010220 CYC140 AC 220 Quizartinib dihydrochloride Quizartinib HCl Quizartinib Inhibitor inhibitor inhibit