Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1].
説明 | PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1]. |
ターゲット&IC50 | CDK9 42:0.10 μM (DC50), CDK9 55:0.14 μM (DC50) |
In vitro | PROTAC CDK9 degrader-5 (Compound 15e) at 1μM for a duration of 6 hours reduces the protein levels of MCL2 and competitively degrades CDK9 in MV411 cells [1]. Additionally, administration of PROTAC CDK9 degrader-5 at the same concentration demonstrates a time-dependent decrease in the protein levels of both MCL2 and CDK9, with sustained inhibition observed for up to 24 hours [1]. |
分子量 | 879.78 |
分子式 | C42H48Cl2N8O9 |
CAS No. | 2935587-89-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PROTAC CDK9 degrader-5 2935587-89-4 PROTAC PROTACs Inhibitor inhibitor inhibit