Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise for research into Alzheimer’s disease (AD) and aging-related disorders[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 210,500 |
50 mg | 約6-8 週間 | ¥ 273,500 |
100 mg | 約6-8 週間 | ¥ 427,000 |
説明 | Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise for research into Alzheimer’s disease (AD) and aging-related disorders[1]. |
In vitro | Q134R (1-10 μM) effectively inhibits NFAT signaling without impacting calcineurin function. It achieves partial suppression of NFAT activity in primary rat astrocytes without hindering the calcineurin-mediated dephosphorylation of non-NFAT targets, both in vivo and in vitro[1]. |
In vivo | Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology[1]. |
別名 | Q134R |
分子量 | 410.39 |
分子式 | C22H17F3N4O |
CAS No. | 2022949-46-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Q134R 2022949-46-6 Q-134R Inhibitor inhibitor inhibit