Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 53,500 |
5 mg | 約 5 days | ¥ 68,500 |
25 mg | 約6-8 週間 | ¥ 210,500 |
50 mg | 約6-8 週間 | ¥ 273,500 |
100 mg | 約6-8 週間 | ¥ 427,000 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 73,000 |
説明 | RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1]. |
In vitro | RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1]. |
分子量 | 391.46 |
分子式 | C23H25N3O3 |
CAS No. | 2351843-48-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (319.32 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. 詳細
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RAS inhibitor Abd-7 2351843-48-4 RAS inhibitor Abd7 RAS inhibitor Abd 7 Inhibitor inhibitor inhibit