store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Retatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide can be used to study obesity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 57,000 |
5 mg | 在庫あり | ¥ 143,000 |
10 mg | 在庫あり | ¥ 229,000 |
25 mg | 在庫あり | ¥ 337,500 |
50 mg | 在庫あり | ¥ 457,000 |
100 mg | 在庫あり | ¥ 617,500 |
説明 | Retatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide can be used to study obesity. |
ターゲット&IC50 | GIPR:0.0643 nM (EC50, human), GIPR:0.057 nM (Ki, human), GLP1R:0.794 nM (EC50, mouse), GIPR:2.8 nM (Ki, mouse), GCGR:5.79 nM (EC50, human), GCGR:2.32 nM (EC50, mouse), GCGR:73 nM (Ki, mouse), GLP1R:7.2 nM (Ki, human), GIPR:0.191 nM (EC50, mouse), GLP1R:1.3 nM (Ki, mouse), GCGR:5.6 nM (Ki, human), GLP1R:0.775 nM (EC50, human) |
In vitro |
Retatrutide (LY3437943) exhibits activity against human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively[1]. For mouse GCGR, GIPR, and GLP-1R, Retatrutide shows activity with EC50 values of 2.32, 0.191, and 0.794 nM, respectively[1]. In terms of binding affinity, Retatrutide has Ki values of 5.6, 0.057, and 7.2 nM for human GCGR, GIPR, and GLP-1R, respectively[1]. Similarly, for mouse GCGR, GIPR, and GLP-1R, Retatrutide exhibits binding affinity with Ki values of 73, 2.8, and 1.3 nM, respectively[1]. |
In vivo |
In vivo, Retatrutide (LY3437943) engages with GCGR and, when administered through subcutaneous injection at a single dose of 0.47 mg/kg, improves glucose tolerance in an ipGTT (intraperitoneal glucose tolerance test) through activation of GIP or GLP-1 receptors[1]. With subcutaneous injections at 10 mL/kg every 3 days in a cycle sustained for 21 days, Retatrutide leads to significant weight reduction and increased energy expenditure through activation of glucagon receptor[1]. |
別名 | LY3437943 |
分子量 | 4731.33 |
分子式 | C221H342N46O68 |
CAS No. | 2381089-83-2 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30 mg/mL (6.34 mM), when pH is adjusted to 7 with NaOH. Sonication is recommended.
DMSO: 30 mg/mL (6.34 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Retatrutide 2381089-83-2 GPCR/G Protein Glucagon Receptor LY3437943 Inhibitor inhibitor inhibit