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Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
説明 | Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis. |
ターゲット&IC50 | IL-17:17 pM (cynomolgus), IL-17:2 pM (human), IL-23:10pM (kd,human), IL-23:10pM (kd,cynomolgus) |
In vitro | With Kds <10 pM, Risankizumab (BI 655066) exhibits high affinity for human and cynomolgus IL23[3]. Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively[2]. |
In vivo | In mice, Risankizumab (BI 655066) inhibits IL23-induced ear swelling and cytokine production following a single intraperitoneal (i.p.) dosage of 1 mg/kg[2]. |
別名 | Risankizumab rzaa, SKYRIZI, ABBV 066, BI-655066 |
分子量 | N/A |
CAS No. | 1612838-76-2 |
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You can also refer to dose conversion for different animals. 詳細
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Risankizumab 1612838-76-2 Immunology/Inflammation IL Receptor Risankizumab rzaa SKYRIZI ABBV 066 BI-655066 Inhibitor inhibitor inhibit