Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 280,000 |
50 mg | 約6-8 週間 | ¥ 365,000 |
100 mg | 約6-8 週間 | ¥ 558,000 |
説明 | Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. |
ターゲット&IC50 | PKA II:9.75 µM (Ki), PKA I:6.05 µM (Ki) |
In vitro | A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2]. |
In vivo | Rp-cAMPS (10 μM, 15 min) reduces the monosynaptic excitatory postsynaptic currents (EPSCs) triggered at the PB-CeLC and BLA-CeLC synapses in tissue slices from arthritic rats, without affecting similar neurons in healthy animals. This inhibition by Rp-cAMPS is notably significant when compared to the pre-drug (ACSF) control measurements in the same cells[2]. |
分子量 | 368.26 |
分子式 | C10H12N5NaO5PS |
CAS No. | 142439-94-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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