Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2]. |
In vivo | In the liver, S-2E undergoes conversion to its active form, S-2E-CoA, which noncompetitively blocks the function of 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase, with inhibition constants (K i) of 18.11 μM and 69.2 μM, respectively [1]. When administered orally at doses ranging from 3 to 30 mg/kg, S-2E effectively reduces the secretion rates of very-low-density lipoprotein (VLDL)-cholesterol and triglycerides in rats treated with Triton WR-1339. Additionally, S-2E simultaneously decreases the levels of total cholesterol and triglycerides in the blood of Zucker fatty rats [1]. |
分子量 | 367.44 |
分子式 | C22H25NO4 |
CAS No. | 155730-92-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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S-2E 155730-92-0 Inhibitor inhibitor inhibit