S-Adenosyl-L-methionine (1,4-butanedisulfonate)
カタログ番号 T79919 CAS
200393-05-1
別名:
Ademetionine (1,4-butanedisulfonate), S-Adenosyl methionine (1,4-butanedisulfonate), AdoMet (1,4-butanedisulfonate)
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-proliferative, pro-apoptotic, and anti-metastatic roles in cancer. SAMe 1,4-butanedisulfonate holds promise in research pertaining to cancer, liver disease, and osteoarthritis [1] [2] [3].
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S-Adenosyl-L-methionine (1,4-butanedisulfonate), CAS 200393-05-1
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生物学的特性に関する説明
化学的特性
保存条件
& 溶解度情報
| 説明 |
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-proliferative, pro-apoptotic, and anti-metastatic roles in cancer. SAMe 1,4-butanedisulfonate holds promise in research pertaining to cancer, liver disease, and osteoarthritis [1] [2] [3]. |
| In vitro |
S-Adenosyl-L-methionine at a concentration of 300 µM for 24 or 48 hours in its 1,4-butanedisulfonate form induces apoptosis and facilitates cell cycle arrest in Cal-33 and JHU-SCC-011 cells [4]. Similarly, S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate reduces migration in both Cal-33 and JHU-SCC-011 cell lines [4]. Additionally, when administered at doses ranging from 5 to 40 μg/mL for 48 hours, 1,4-butanedisulfonate-derivative S-Adenosyl-L-methionine modulates the expression of DNMTs, thereby preserving the anticancer efficacy of 5-FU [5].
|
| In vivo |
S-Adenosyl-L-methionine (30 mg/kg, orally administered for 3 consecutive days) 1,4-butanedisulfonate has been shown to prevent ASD-like behaviors induced by early postnatal valproate exposure in young mice [6]. Additionally, at doses of 50 and 100 mg/kg administered orally, 1,4-butanedisulfonate exhibits antiepileptic, memory-enhancing, and antioxidant properties in a pentylenetetrazole-induced rat model of epilepsy [7].
|
| 別名 |
Ademetionine (1,4-butanedisulfonate), S-Adenosyl methionine (1,4-butanedisulfonate), AdoMet (1,4-butanedisulfonate)
|
| 分子量 |
616.69
|
| 分子式 |
C19H32N6O11S3 |
| CAS No. |
200393-05-1 |
保存条件
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
投与量変換
You can also refer to dose conversion for different animals.
詳細
In vivo投与量計算 (透明溶液)
ステップ1: 以下の情報を入力してください
溶媒の組成を入力してください
計算器
モル濃度計算機
希釈計算機
再構成計算
分子量計算機
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技術サポート
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
200393-05-1
Metabolism
Endogenous Metabolite
Ademetionine (1,4-butanedisulfonate)
S-Adenosyl methionine (1,4-butanedisulfonate)
AdoMet (1,4-butanedisulfonate)
Inhibitor
inhibitor
inhibit
