Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 17,000 | |||
10 mg | 在庫あり | ¥ 28,500 | |||
25 mg | 在庫あり | ¥ 66,500 | |||
50 mg | 在庫あり | ¥ 123,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 18,500 |
説明 | SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders. |
ターゲット&IC50 | 5-HT7 receptor (human):5.64 (pKi), 5-HT2A receptor (human):7.01 (pKi), 5-HT2B receptor (human):7.2 (pKi), 5-HT6 receptor (human):6.5 (pKi) |
In vitro | SB 243213 exhibits low affinity for cloned human 5-HT1D, 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, and 5-HT7 receptors[1]. |
In vivo | In experimentally naive male Sprague-Dawley rats weighing 220-300 g, SB 243213 (0.1, 0.3, 1, 3, 10 mg/kg; oral administration; 1 hour pre-test) dose-dependently and significantly increased the duration of social interaction in brightly lit conditions and in an unfamiliar test box, lasting for 15 minutes[1]. |
分子量 | 428.41 |
分子式 | C22H19F3N4O2 |
CAS No. | 200940-22-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (233.42 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SB 243213 200940-22-3 GPCR/G Protein Neuroscience 5-HT Receptor SB243213 SB-243213 Inhibitor inhibitor inhibit