Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacological properties, including anti-HIV and anticancer activities[1][2].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 22,500 |
5 mg | 約 5 days | ¥ 45,500 |
25 mg | 約6-8 週間 | ¥ 144,000 |
50 mg | 約6-8 週間 | ¥ 187,000 |
100 mg | 約6-8 週間 | ¥ 278,000 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 43,500 |
説明 | Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacological properties, including anti-HIV and anticancer activities[1][2]. |
In vitro | Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3]. Cell Viability Assay[3] Cell Line: SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells |
In vivo | Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1]. Animal Model: 5-6-week-old male C57Bl/6 mice (body weight 18-20 g)[1] |
分子量 | 268.22 |
分子式 | C15H8O5 |
CAS No. | 1259330-61-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Sparstolonin B 1259330-61-4 Inhibitor inhibitor inhibit