Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1]. |
In vitro | STAT3-IN-9 (compound C6) demonstrated potent anti-tumor activity in vitro, with IC50 values of 0.16, 5.80, 1.63, 5.73, >25, and >25 μM against MDA-MB-468, MDA-MB-231, HepG2, A549, U251, and HCT116 cells, respectively, after 48 hours. Additionally, at concentrations of 0, 0.2, 1.0, and 5.0 μM over 24 hours, STAT3-IN-9 selectively inhibited the activation of STAT3 (Tyr705) without affecting STAT1 (Tyr701) phosphorylation. At doses of 0, 0.2, and 1 μM, it also induced apoptosis via the mitochondrial Caspase-dependent pathway and caused cell cycle arrest at the G2/M phase in a dose-dependent manner within 24 hours. These findings underscore STAT3-IN-9's targeted action in inhibiting tumor cell proliferation and promoting apoptosis, without interfering with STAT1 activation. |
分子量 | 391.42 |
分子式 | C22H21N3O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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STAT3-IN-9 Inhibitor inhibitor inhibit