Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | お問い合わせ | ¥ 86,000 |
10 mg | お問い合わせ | ¥ 152,500 |
25 mg | お問い合わせ | ¥ 303,000 |
50 mg | お問い合わせ | ¥ 493,500 |
100 mg | お問い合わせ | ¥ 741,500 |
1 mL * 10 mM (in DMSO) | お問い合わせ | ¥ 91,500 |
説明 | Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1]. |
In vitro | Syk-IN-4 is a potent inhibitor of hERG with an IC50 of 3.0 μM[1].Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI50s of 0.24 and 2.6 μM, respectively[1]. |
In vivo | Syk-IN-4 demonstrates moderate oral bioavailability (60%) when administered orally (1 mg/kg) in male Hans Wistar rats[1], while showing high plasma clearance (151 mL/min/kg) and large volume of distribution (1.0 L/kg respectively) upon intravenous administration (0.5 mg/kg) in the same animal model[1]. |
分子量 | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (148.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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