keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tat-βsyn-degron, an α-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an α-synuclein binding domain (βsyn) representing amino acids 36-45 of β-synuclein, and a proteasomal targeting domain (degron). It effectively binds to recombinant α-synuclein, demonstrating a significant reduction in α-synuclein levels in primary rat cortical neuron cultures.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 14,500 |
5 mg | お問い合わせ | ¥ 68,000 |
10 mg | お問い合わせ | ¥ 129,000 |
25 mg | お問い合わせ | ¥ 284,500 |
説明 | Tat-βsyn-degron, an α-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an α-synuclein binding domain (βsyn) representing amino acids 36-45 of β-synuclein, and a proteasomal targeting domain (degron). It effectively binds to recombinant α-synuclein, demonstrating a significant reduction in α-synuclein levels in primary rat cortical neuron cultures. |
In vivo | Administrating Tat-βsyn-degron at 40 mg/kg reduces α-synuclein levels in the brains of M38 transgenic mice overexpressing human A53T mutant α-synuclein. It also diminishes phosphorylated α-synuclein levels in the substantia nigra and the pons, alongside neuroinflammation in mice exposed to α-synuclein preformed fibrils, simulating spreading synucleinopathy. Furthermore, at a dosage of 6 µmol/kg intraperitoneally, Tat-βsyn-degron ameliorates dopaminergic neuron loss and improves motor deficits in mice suffering from MPTP-induced Parkinson’s disease, underscoring its potential therapeutic benefit. |
分子量 | 3146.67 |
分子式 | C132H237N59O31.XCF3COOH |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 50 mg/ml
PBS pH 7.2: 1 mg/ml
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tat-βsyn-degron TFA Inhibitor inhibitor inhibit