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Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.
説明 | Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes. |
In vitro | Teplizumab induces human CD8+ T-cell proliferation (10 ng/mL-10 μg/mL, 5 days)[3]. Teplizumab increases the expression of CD25 and intracellular CTLA4 on CD8+ cells (freshly isolated PBMCs) after 6 days[2]. |
In vivo | In NSG mice, Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablates the treatment effects of the drug on graft survival[3]. |
別名 | PRV-031, MGA-031 |
分子量 | N/A |
CAS No. | 876387-05-2 |
store at low temperature
store at -20°C
You can also refer to dose conversion for different animals. 詳細
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Teplizumab 876387-05-2 Others PRV-031 MGA-031 Inhibitor inhibitor inhibit