Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thiethylperazine is a phenothiazine derivative. Thiethylperazine is a histamine H1 receptor and dopamine D2 receptor antagonist with oral activity. Thiethylperazine is also a selective ABCC1 activator, which can reduce amyloid-β (Aβ) load in mice. Thiethylperazine has antipsychotic, antiemetic and antibacterial effects.
説明 | Thiethylperazine is a phenothiazine derivative. Thiethylperazine is a histamine H1 receptor and dopamine D2 receptor antagonist with oral activity. Thiethylperazine is also a selective ABCC1 activator, which can reduce amyloid-β (Aβ) load in mice. Thiethylperazine has antipsychotic, antiemetic and antibacterial effects. |
In vitro | Thiethylperazine boosts the efficacy of the antibiotic Vancomycin against both Vancomycin-sensitive and resistant strains of E. faecalis, starting at a minimal concentration of 2 μg/mL. It effectively inhibits the growth of Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299, and Vancomycin-resistant E. faecalis (VREF) isolates, displaying MIC (minimum inhibitory concentration) values of 8 μg/mL, 16 μg/mL, and 8 μg/mL, respectively [3]. |
In vivo | Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) markedly decreases Aβ42 levels in young APP/PS1 mice, utilizing an animal model comprising young mice genetically modified to express the amyloid precursor protein (APPswe) and mutant presenilin-1 (PS1) [2]. This dosage and administration method demonstrates a significant reduction in Aβ42 levels within this specific mouse model, offering insights into potential therapeutic approaches for Alzheimer's disease. |
分子量 | 399.62 |
分子式 | C22H29N3S2 |
CAS No. | 1420-55-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Thiethylperazine 1420-55-9 Inhibitor inhibitor inhibit