Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.3
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 33,000 |
5 mg | 約 35 days | ¥ 126,500 |
10 mg | 約 35 days | ¥ 173,500 |
25 mg | 約 35 days | ¥ 392,500 |
説明 | Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.3 |
分子量 | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: Slightly soluble
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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Tpl2 Kinase Inhibitor (hydrochloride) Tpl-2 Kinase Inhibitor (hydrochloride) Tpl2 Kinase Inhibitor Inhibitor inhibitor inhibit