Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. Additionally, TrxR-IN-5 demonstrates pronounced effects against cancer proliferation and metastasis [1].
説明 | TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. Additionally, TrxR-IN-5 demonstrates pronounced effects against cancer proliferation and metastasis [1]. |
In vivo | TrxR-IN-5 (compound 4f), administered intraperitoneally (IP) at doses ranging from 0 to 25 mg/kg once to BALB/c nude mice with MDA-MB-231 xenografts, demonstrates significant inhibitory effects on solid breast cancer tumors in vivo [1]. |
分子量 | 382.45 |
分子式 | C26H22O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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TrxR-IN-5 Inhibitor inhibitor inhibit