Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1]. |
In vitro | VEGFR-2-IN-19 (Compound 15b) exhibited antiproliferative effects on cancer cells, including HT-29 and A549 lines, within a concentration range of 0-100 μM over 48 hours, as evidenced by IC50 values of 3.38±1.3 μM and 0.63±0.04 μM, respectively. At lower concentrations (0-10 μM, 48 hours), it effectively inhibited VEGFR2 phosphorylation and downregulated the Raf/MEK/ERK signaling pathway, leading to increased apoptosis and G0/G1 cell cycle arrest in HT-29 cells. Additionally, VEGFR-2-IN-19 enhanced intracellular levels of reactive oxygen species in HT-29 cells after 12 hours. Western blot analyses confirmed dose-dependent inhibition of VEGFR2, c-Raf, ERK1/2, and MEK phosphorylation, along with modulation of apoptosis-related proteins (caspase-3, Bax, Bcl-2). Apoptosis and cell cycle analyses revealed a significant increase in early and late apoptotic cell counts and alterations in cell cycle progression, respectively, indicating potent antitumor activities of VEGFR-2-IN-19. |
分子量 | 345.39 |
分子式 | C21H19N3O2 |
CAS No. | 2456315-41-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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VEGFR-2-IN-19 2456315-41-4 Inhibitor inhibitor inhibit