Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1]. |
In vitro | VEGFR-2-IN-23 (compound 11b) demonstrates antitumor efficacy by presenting IC50 values of 23, 0.8, 1.3, and 46 nM against PC3, DU145, MCF-7, and MDA-MB435 cancer cell lines, respectively [1]. |
In vivo | VEGFR-2-IN-23, administered intraperitoneally at doses of 5 and 10 mg/kg, effectively suppresses tumor growth in MCF-7 xenograft models [1]. |
分子量 | 381.39 |
分子式 | C22H15N5O2 |
CAS No. | 2411174-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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VEGFR-2-IN-23 2411174-53-1 Inhibitor inhibitor inhibit