Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WAY-649123 is an active molecule that exhibits (in vitro) antagonistic properties against (alpha-1A adrenergic receptors), with a (pKi) of 8.9. It also demonstrates a 70-fold selectivity over (alpha-1B) and 100-fold selectivity over (alpha-1D) subtypes. This compound has been shown to cross the blood-brain barrier (BBB) effectively in preclinical trials. Furthermore, WAY-649123 exhibits a high level of oral bioavailability and a favorable pharmacokinetic profile, making it a potential candidate for clinical development targeting conditions associated with (alpha-1A) receptors.
説明 | WAY-649123 is an active molecule that exhibits (in vitro) antagonistic properties against (alpha-1A adrenergic receptors), with a (pKi) of 8.9. It also demonstrates a 70-fold selectivity over (alpha-1B) and 100-fold selectivity over (alpha-1D) subtypes. This compound has been shown to cross the blood-brain barrier (BBB) effectively in preclinical trials. Furthermore, WAY-649123 exhibits a high level of oral bioavailability and a favorable pharmacokinetic profile, making it a potential candidate for clinical development targeting conditions associated with (alpha-1A) receptors. |
分子量 | 305.28 |
分子式 | C16H13F2NO3 |
CAS No. | 801244-46-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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WAY-649123 801244-46-2 Inhibitor inhibitor inhibit