Family Asclepiadaceae is also called as Milky weed family. This family has more than 384 genera and around 2900 species. Calotropis procera (Aiton) Dryand. is an evergreen, perennial shrub of the family Asclepiadaceae with an exceptional ability to adapt and maintain productivity in severe arid conditions. The decoction of aboveground parts is being used to treat fever, joint pain, muscular spasm, and constipation in Saudi Arabia. The medicinal attributes of C. procera can be credited to secondary metabolites and cardiotonic substances present in the plant.