Vascular Endothelial Growth Factor Receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding. In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. Inhibitors of VEGFR are used in the treatment of cancer.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
|
Human | Human Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protei... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His)
VEGFR2/KDR Protein, Human, Recombinant (His)
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-00949 | VEGFR3/FLT4 Protein, Human, Recombinant (His)
VEGFR3/FLT4 Protein, Human, Recombinant (His)
|
Human | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept... | |||
TMPY-00637 | FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His)
|
Human | HEK293 |
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F... | |||
TMPY-01936 | VEGFR3/FLT4 Protein, Mouse, Recombinant (His)
VEGFR3/FLT4 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept... | |||
TMPY-06780 | FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F... | |||
TMPY-06665 | FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
|
Mouse | HEK293 |
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F... | |||
TMPY-06620 | VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept... | |||
TMPY-05733 | FLT1 Protein, Mouse, Recombinant (His)
FLT1 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F... | |||
TMPY-05657 | VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-05610 | VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-05382 | VEGFR2/KDR Protein, Cynomolgus, Recombinant (His)
VEGFR2/KDR Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04940 | VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04924 | VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated
VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04802 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04796 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04795 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04794 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
|
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-04530 | VEGFR2/KDR Protein, Human, Recombinant (His & GST)
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
|
Human | Baculovirus-Insect Cells |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr... | |||
TMPY-03299 | FLT1 Protein, Rat, Recombinant (His)
FLT1 Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F... |