15-PGDH Protein, Mouse, Recombinant (His)

15-PGDH Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.6 kDa and the accession number is Q8VCC1.

15-PGDH Protein, Mouse, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 138,000

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説明	15-PGDH Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.6 kDa and the accession number is Q8VCC1.

Species	Mouse
Expression Host	E. coli
Tag	C-His
Accession Number	Q8VCC1
別名	15-PGDH, AV026552, hydroxyprostaglandin dehydrogenase 15-(NAD)
Construction	The Mouse HPGD (Q8VCC1) (Met 1-Ser 269) was expressed, with a polyhistide tag at the C-terusmin.
Protein Purity	> 90 % as determined by SDS-PAGE
分子量	30.6 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Supplied as sterile PBS, pH 8.0, 20% glycerol.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.

参考文献

1. Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33. 2. McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41. 3. Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73. 4. Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.

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15-PGDH Protein, Mouse, Recombinant (His)

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