Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 47.5 kDa and the accession number is Q9UNG2.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 約5 days | ¥ 187,000 |
500 μg | 約5 days | ¥ 746,000 |
1 mg | 約5 days | ¥ 1,248,500 |
説明 | Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 47.5 kDa and the accession number is Q9UNG2. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | N-His-Flag |
Accession Number | Q9UNG2 |
別名 | TL6, GITR Ligand, TNFSF18, AITRL, GITRL |
Construction | Gln50-Ser177 |
Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
分子量 | 47.5 kDa (predicted). Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result. |
Endotoxin | < 1 EU/μg by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. |
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GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated TL6 GITR Ligand TL-6 TNFSF18 TL 6 AITRL TNFSF-18 TNFSF 18 GITRL recombinant recombinant-proteins proteins protein