MOG Protein, Mouse, Recombinant (aa 30-149, His)

MOG Protein, Mouse, Recombinant (aa 30-149, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is Q61885.

MOG Protein, Mouse, Recombinant (aa 30-149, His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 161,000

バルクのお問い合わせ

説明	MOG Protein, Mouse, Recombinant (aa 30-149, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is Q61885.

Species	Mouse
Expression Host	E. coli
Tag	His
Accession Number	Q61885
別名	B230317G11Rik, myelin oligodendrocyte glycoprotein
Construction	The Mouse MOG (Q61885) extracellular domain (Gly 29-Thr 156) was expressed, with a C-terminal polyhistidine tag.
Protein Purity	≥ 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	16 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 5. 5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in the oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce demyelinating multiple sclerosis-like diseases in experimental animals.

参考文献

1. Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23. 2. Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18. 3. Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.

Calculator

Reconstitution Calculator

Recombinant Proteins Dilute Calculator

Specific Activity Calculator

bottom

MOG Protein, Mouse, Recombinant (aa 30-149, His)

参考文献

Calculator

技術サポート

Keywords