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ACOD1 Protein, Human, Recombinant (His)

カタログ番号 TMPH-01098
別名: Aconitate decarboxylase 1, IRG1, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, Immune-responsive gene 1 protein, CAD, Aconitate decarboxylase

ACOD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.6 kDa and the accession number is A6NK06.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ACOD1 Protein, Human, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
20 μg 約20 days ¥ 83,000
100 μg 約20 days ¥ 156,000
1 mg 約20 days ¥ 528,000
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生物学的特性に関する説明
Technical Params
Product Properties
説明 ACOD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.6 kDa and the accession number is A6NK06.
Species Human
Expression Host E. coli
Tag N-terminal 6xHis-tagged
Accession Number A6NK06
別名 Aconitate decarboxylase 1, IRG1, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, Immune-responsive gene 1 protein, CAD, Aconitate decarboxylase
Amino Acid MMLKSITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLGTTTEVFHIASQYSKIYSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDMPKRFHPPSVVGTLGSAAAASKFLGLSSTKCREALAIAVSHAGAPMANAATQTKPLHIGNAAKHGIEAAFLAMLGLQGNKQVLDLEAGFGAFYANYSPKVLPSIASYSWLLDQQDVAFKRFPAHLSTHWVADAAASVRKHLVAERALLPTDYIKRIVLRIPNVQYVNRPFPVSEHEARHSFQYVACAMLLDGGITVPSFHECQINRPQVRELLSKVELEYPPDNLPSFNILYCEISVTLKDGATFTDRSDTFYGHWRKPLSQEDLEEKFRANASKMLSWDTVESLIKIVKNLEDLEDCSVLTTLLKGPSPPEVASNSPACNNSITNLS Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Construction 1-481 aa
Protein Purity > 85% as determined by SDS-PAGE.
分子量 58.6 kDa (predicted)
Formulation Tris-based buffer,50% glycerol
Reconstitution A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.

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技術サポート

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

ACOD1 Protein, Human, Recombinant (His) Aconitate decarboxylase 1 IRG1 Cis-aconitate decarboxylase Cis-aconitic acid decarboxylase Immune-responsive gene 1 protein CAD Aconitate decarboxylase recombinant recombinant-proteins proteins protein