Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
カタログ番号 TMPJ-01471
別名:
Activin A, INHBA, Inhibin beta A chain, Inhibin β A chain
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
1. Measured by its ability to induce SMAD signaling in 293-Activin A Res cells. The ED50 for this effect is 1.3 ng/mL.
2. Human intestinal organoids (ipsc source) were cultured with Activin A , BMP-4, EGF, Wnt3a, Noggin, R-spondin 1 and FGF-4 .
説明
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
Activin A, INHBA, Inhibin beta A chain, Inhibin β A chain
Amino Acid
Gly311-Ser426
Construction
Recombinant Human Activin A is produced by our Mammalian expression system and the target gene encoding Gly311-Ser426 is expressed.
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin
Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
Formulation
Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
Reconstitution
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Stability & Storage
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping
The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
Research Background
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
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