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ACVR2A Protein, Mouse, Recombinant (His)

カタログ番号 TMPY-01447
別名: ActrIIa, activin A receptor, type IIA, Acvr2, TactrII

ACVR2A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A2AI38.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ACVR2A Protein, Mouse, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
100 μg 在庫あり ¥ 88,500
200 μg 約5 days ¥ 156,500
500 μg 約5 days ¥ 330,500
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
生物学的情報 Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.6-3 μg/mL in the presence of 10 ng/ml Recombinant Human Activin A.

説明 ACVR2A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A2AI38.
Species Mouse
Expression Host HEK293 Cells
Tag His
Accession Number A2AI38
別名 ActrIIa, activin A receptor, type IIA, Acvr2, TactrII
Construction The extracellular domain of Mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was expressed, with a C-terminal polyhistidine tag.
Protein Purity ≥ 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

分子量 14.8 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

参考文献

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Keywords

ACVR2A Protein, Mouse, Recombinant (His) ActrIIa activin A receptor, type IIA Acvr2 TactrII recombinant recombinant-proteins proteins protein