AKR1C3 Protein, Human, Recombinant (His)

カタログ番号 TMPJ-00962

別名: 3-Alpha-HSD Type 2, 17-β-Hydroxysteroid Dehydrogenase Type 5, Chlordecone Reductase Homolog HAKRb, Dihydrodiol Dehydrogenase, 17-Beta-Hydroxysteroid Dehydrogenase Type 5, 17-Beta-HSD 5, 17-β-HSD 5, 3-α-HSD Type II Brain, Aldo-Keto Reductase Family 1 Member C3, 3-α-Hydroxysteroid Dehydrogenase Type 2, 3-Alpha-Hydroxysteroid Dehydrogenase Type 2, 3-α-HSD Type 2, 3-Alpha-HSD Type II Brain

AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.

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AKR1C3 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
10 μg	約5 days	￥ 42,500
50 μg	約5 days	￥ 125,000
500 μg	約5 days	￥ 436,000
1 mg	約5 days	￥ 626,500

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DATASHEET SDS

生物学的特性に関する説明

Technical Params

Product Properties

説明

Species	Human
Expression Host	Human Cells
Tag	C-6His
Accession Number	P42330
別名	3-Alpha-HSD Type 2, 17-β-Hydroxysteroid Dehydrogenase Type 5, Chlordecone Reductase Homolog HAKRb, Dihydrodiol Dehydrogenase, 17-Beta-Hydroxysteroid Dehydrogenase Type 5, 17-Beta-HSD 5, 17-β-HSD 5, 3-α-HSD Type II Brain, Aldo-Keto Reductase Family 1 Member C3, 3-α-Hydroxysteroid Dehydrogenase Type 2, 3-Alpha-Hydroxysteroid Dehydrogenase Type 2, 3-α-HSD Type 2, 3-Alpha-HSD Type II Brain
Amino Acid	Met1-Tyr323
Construction	Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	38 KDa, reducing conditions

Endotoxin	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Sucrose, 2% Glycine, 100mM NaCl, 0.05% Tween 80，pH 6.0.
Reconstitution	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Stability & Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background	AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.

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Keywords

AKR1C3 Protein, Human, Recombinant (His) 3-Alpha-HSD Type 2 3-a-HSD Type II Brain 17-β-Hydroxysteroid Dehydrogenase Type 5 Chlordecone Reductase Homolog HAKRb Dihydrodiol Dehydrogenase 17-Beta-Hydroxysteroid Dehydrogenase Type 5 17-Beta-HSD 5 17-β-HSD 5 17-b-Hydroxysteroid Dehydrogenase Type 5 3-a-HSD Type 2 3-α-HSD Type II Brain 17-b-HSD 5 Aldo-Keto Reductase Family 1 Member C3 3-α-Hydroxysteroid Dehydrogenase Type 2 3-a-Hydroxysteroid Dehydrogenase Type 2 3-Alpha-Hydroxysteroid Dehydrogenase Type 2 3-α-HSD Type 2 3-Alpha-HSD Type II Brain recombinant recombinant-proteins proteins protein