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ALK-4/ACVR1B Protein, Human, Recombinant (hFc)

カタログ番号 TMPY-05483
別名: ACVRLK4, ACTRIB, ALK4, activin A receptor, type IB, SKR2

ALK-4/ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ALK-4/ACVR1B Protein, Human, Recombinant (hFc)
パッケージサイズ 在庫状況 単価(税別)
200 μg 約5 days ¥ 207,500
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 ALK-4/ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1.
Species Human
Expression Host HEK293 Cells
Tag C-hFc
Accession Number P36896-1
別名 ACVRLK4, ACTRIB, ALK4, activin A receptor, type IB, SKR2
Construction The Human ACVR1B (NP_004293.1) (Met1-Glu126) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity > 90 % as determined by SDS-PAGE.
分子量 38.1 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

参考文献

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Keywords

ALK-4/ACVR1B Protein, Human, Recombinant (hFc) ALK-4 ALK 4 ACVRLK4 ACTRIB ALK4 activin A receptor, type IB ACVRLK-4 SKR-2 ACVRLK 4 SKR2 SKR 2 recombinant recombinant-proteins proteins protein