Aminopeptidase A Protein, Rat, Recombinant (aa 41-945, His)

Aminopeptidase A Protein, Rat, Recombinant (aa 41-945, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 106 kDa and the accession number is P50123-1.

Aminopeptidase A Protein, Rat, Recombinant (aa 41-945, His)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 138,000

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説明	Aminopeptidase A Protein, Rat, Recombinant (aa 41-945, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 106 kDa and the accession number is P50123-1.

Species	Rat
Expression Host	Baculovirus Insect Cells
Tag	N-His
Accession Number	P50123-1
別名	ENPEP, glutamyl aminopeptidase
Construction	The mature form of Rat ENPEP (P50123-1) (Arg41-Pro945) was expressed,with a polyhistide tag at the N-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	106 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	ENPEP, also known as aminopeptidase A, is a member of the peptidase M1 family. Members of this family are involved in response to cadmium ion and proteolysis. They located in 6 components and are expressed in 26 plant structures. ENPEP is expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. It also can be detected in a variety of other tissues. ENPEP probably plays a role in regulating growth and differentiation of early B-lineage cells. It also may play a role in the catabolic pathway of the renin-angiotensin system. ENPEP is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. It degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.

参考文献

1. Speth RC,et al.(2008) The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain. Heart Fail Rev. 13(3):299-309. 2. Rose JE,et al.(2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med. 16(7-8):247-53. 3. Pérez I,et al.(2009) Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma. Head Neck. 31(10):1335-40.

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Aminopeptidase A Protein, Rat, Recombinant (aa 41-945, His)

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