AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)

カタログ番号 TMPY-02949

別名: ERF1, hAP-2g, transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma), transcription factor AP-2 γ (activating enhancer binding protein 2 γ), AP2 γ/TFAP2C, AP2-GAMMA, TFAP2G, AP2-γ

TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).

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AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 161,000

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Product Properties

参考文献

説明

Species	Human
Expression Host	E. coli
Tag	N-His
Accession Number	Q92754
別名	ERF1, hAP-2g, transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma), transcription factor AP-2 γ (activating enhancer binding protein 2 γ), AP2 γ/TFAP2C, AP2-GAMMA, TFAP2G, AP2-γ
Construction	mature form of Human TFAP2C (Q92754) (Leu128-Val223)
Protein Purity	> 98 % as determined by SDS-PAGE
分子量	12.3 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).

参考文献

1. Woodfield GW,et al.(2009) Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. Clin Cancer Res. 15 (11): 3672-9. 2. Zhao C,et al.(2003) Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Cancer. 98 (1): 18-23. 3. Woodfield GW,et al.(2007) TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling. Cancer Res. 67 (18): 8439-43. 4. Penna E,et al.(2011) microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J. 30 (10): 1990-2007. 5. Woodfield GW,et al.(2010) Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 49 (10): 948-62.

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Keywords

AP2 Gamma/TFAP2C Protein, Human, Recombinant (His) ERF1 activating enhancer binding protein 2 gamma transcription factor AP-2 gamma hAP-2g transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) transcription factor AP-2 γ (activating enhancer binding protein 2 γ) AP2 γ/TFAP2C AP2-GAMMA TFAP2G ERF-1 ERF 1 AP2-γ recombinant recombinant-proteins proteins protein