Asprosin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-8xHis tag. The predicted molecular weight is 25-35 KDa and the accession number is P35555.
| 説明 |
Asprosin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-8xHis tag. The predicted molecular weight is 25-35 KDa and the accession number is P35555. |
| Species |
Human
|
| Expression Host |
HEK293 Cells
|
| Tag |
N-8xHis
|
| Accession Number |
P35555
|
| 別名 |
Asprosin, FBN, Fibrillin-1, FBN1
|
| Amino Acid |
Ser2732-His2871
|
| Construction |
Ser2732-His2871
|
| Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
|
| 分子量 |
25-35 KDa (reducing condition)
|
| Endotoxin |
< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
|
| Formulation |
Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
|
| Reconstitution |
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
|
| Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
|
| Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
|
| Research Background |
Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In the liver asprosin activates rapid glucose release by a cAMP-dependent pathway. The glucose release by the liver into the blood stream is vital for brain function and survival during fasting. People with neonatal progeroid syndrome lack asprosin, while people with insulin resistance have it in abundance. In animal tests asprosin showed potential for treating type 2 diabetes. When antibodies targeting asprosin were injected into diabetic mice, blood glucose and insulin levels improved.
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