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B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (aa 21-119, His)

カタログ番号 TMPJ-01236
別名: Beta-2-Microglobulin, β-2-Microglobulin, B2M

B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (aa 21-119, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 14 KDa and the accession number is Q8SPW0.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (aa 21-119, His)
パッケージサイズ 在庫状況 単価(税別)
10 μg 約5 days ¥ 13,000
50 μg 約5 days ¥ 38,500
500 μg 約5 days ¥ 310,000
1 mg 約5 days ¥ 461,500
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生物学的特性に関する説明
Technical Params
Product Properties
説明 B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (aa 21-119, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 14 KDa and the accession number is Q8SPW0.
Species Cynomolgus
Expression Host HEK293 Cells
Tag C-6xHis
Accession Number Q8SPW0
別名 Beta-2-Microglobulin, β-2-Microglobulin, B2M
Amino Acid Ile21-Met119
Construction Ile21-Met119
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 14 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

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技術サポート

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (aa 21-119, His) Beta-2-Microglobulin β-2-Microglobulin B2M b-2-Microglobulin recombinant recombinant-proteins proteins protein