B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
カタログ番号 TMPJ-00176
別名:
B7H4T-cell costimulatory molecule B7x, FLJ22418, B7XPRO1291, B7x, V-set domai, B7-H4, B7S1, B7h.5, Immune costimulatory protein B7-H4, Vtcn1, B7S1VCTN1, V-set domain containing T cell activation inhibitor 1, T cell costimulatory molecule B7x, Protein B7S1
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
| パッケージサイズ |
在庫状況 |
単価(税別) |
| 20 μg |
約5 days |
￥ 81,500 |
| 100 μg |
約5 days |
￥ 221,000 |
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生物学的特性に関する説明
Technical Params
Product Properties
| 説明 |
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation. |
| Species |
Human
|
| Expression Host |
HEK293 Cells
|
| Tag |
C-hFc-Avi
|
| Accession Number |
Q7Z7D3
|
| 別名 |
B7H4T-cell costimulatory molecule B7x, FLJ22418, B7XPRO1291, B7x, V-set domai, B7-H4, B7S1, B7h.5, Immune costimulatory protein B7-H4, Vtcn1, B7S1VCTN1, V-set domain containing T cell activation inhibitor 1, T cell costimulatory molecule B7x, Protein B7S1
|
| Amino Acid |
Phe29-Ala258
|
| Construction |
Phe29-Ala258
|
| Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
|
| 分子量 |
70-95 KDa (reducing condition)
|
| Endotoxin |
< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
|
| Formulation |
Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
|
| Reconstitution |
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
|
| Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
|
| Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
|
| Research Background |
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
|
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技術サポート
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Keywords
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
B7H4T-cell costimulatory molecule B7x
FLJ22418
B7XPRO1291
B7x
V-set domai
B7-H4
B7XPRO 1291
B7S1
FLJ-22418
B7h.5
Immune costimulatory protein B7-H4
Vtcn1
B7S1VCTN1
V-set domain containing T cell activation inhibitor 1
T cell costimulatory molecule B7x
Protein B7S1
B7XPRO-1291
FLJ 22418
recombinant
recombinant-proteins
proteins
protein
