BCA-1 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.1 kDa and the accession number is XP_851619.3.
説明 | BCA-1 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.1 kDa and the accession number is XP_851619.3. |
Species | Canine |
Expression Host | E. coli |
Tag | N-His |
Accession Number | XP_851619.3 |
別名 | chemokine (C-X-C motif) ligand 13 |
Construction | canine CXCL13 (XP_851619.3) (Val23-Asn110) |
Protein Purity | > 95 % as determined by SDS-PAGE |
分子量 | 12.1 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL). |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
BCA-1 Protein, Canine, Recombinant (His) chemokine (C-X-C motif) ligand 13 recombinant recombinant-proteins proteins protein