Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. Beta Klotho Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 109.91 kDa and the accession number is Q99N32-1.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 約5 days | ¥ 117,500 |
500 μg | 約5 days | ¥ 468,500 |
1 mg | 約5 days | ¥ 782,500 |
説明 | Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. Beta Klotho Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 109.91 kDa and the accession number is Q99N32-1. |
Species | Mouse |
Expression Host | HEK293 Cells |
Tag | C-His |
Accession Number | Q99N32-1 |
別名 | Klotho beta, β-klotho, MGC142213, βKlotho, β Klotho, KLB, beta-klotho, klotho beta like, BKL, klotho β like, betaKlotho, Klotho β |
Construction | Phe53-Pro994 |
Protein Purity | > 90% as determined by Tris-Bis PAGE; > 90% as determined by HPLC |
分子量 | 109.91 kDa (predicted). Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result. |
Endotoxin | < 1 EU/μg by the LAL method. |
Formulation | Supplied as 0.22 μm filtered solution in PBS (pH 7.4). |
Stability & Storage |
It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. |
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Beta Klotho Protein, Mouse, Recombinant (His) Klotho beta β-klotho MGC142213 MGC 142213 bKlotho βKlotho β Klotho KLB beta-klotho Klotho b klotho beta like BKL klotho β like klotho b like MGC-142213 betaKlotho b-klotho Klotho β recombinant recombinant-proteins proteins protein