C-ABL/ABL1 Protein, Human, Recombinant (GST)

カタログ番号 TMPY-04396

別名: v-abl, ABL, JTK7, ABL proto-oncogene 1, non-receptor tyrosine kinase, c-ABL1, c-ABL, p150, bcr/abl

c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

C-ABL/ABL1 Protein, Human, Recombinant (GST)

パッケージサイズ	在庫状況	単価(税別)
20 μg	在庫あり	￥ 54,500
100 μg	約5 days	￥ 122,000
200 μg	約5 days	￥ 208,500
500 μg	約5 days	￥ 422,500

バルクのお問い合わせ

バッチを選択

COA DATASHEET SDS

生物学的特性に関する説明

Technical Params

Product Properties

参考文献

生物学的情報

The specific activity was determined to be 240 nmol/min/mg using synthetic Abl peptide (EAIYAAPFAKKK) as substrate.

説明

Species	Human
Expression Host	Baculovirus-Insect Cells
Tag	GST
Accession Number	P00519-2
別名	v-abl, ABL, JTK7, ABL proto-oncogene 1, non-receptor tyrosine kinase, c-ABL1, c-ABL, p150, bcr/abl
Construction	A DNA sequence encoding the amino acid sequence (Pro 137-Ser 554) of human ABL1 isoform B (NP_009297.2) was fused with the GST tag at the N-terminus.
Protein Purity	> 75 % as determined by SDS-PAGE
分子量	74 kDa (predicted)

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Supplied as sterile 20mM Tris，300mM NaCl, 25% glycerol; 0. 1mM PMSF, 0. 1mM EDTA，0. 5mM GSH，pH7.5. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Qiu Z,et al.(2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 107(3): 1136-41. 2. Huang Y,et al.(2008) The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood. 112(1): 111-9. 3. Sirvent A,et al.(2008) Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell. 100(11): 617-31.Shaul Y,et al.(2005) Role of c-Abl in the DNA damage stress response. Cell Res. 15(1): 33-5.

Calculator

Reconstitution Calculator

Recombinant Proteins Dilute Calculator

Specific Activity Calculator

bottom

技術サポート

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

C-ABL/ABL1 Protein, Human, Recombinant (GST) JTK-7 v-abl ABL JTK7 ABL proto-oncogene 1, non-receptor tyrosine kinase c-ABL1 JTK 7 c-ABL p150 bcr/abl recombinant recombinant-proteins proteins protein