Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
50 μg | 在庫あり | ¥ 73,500 |
100 μg | 約5 days | ¥ 130,500 |
200 μg | 約5 days | ¥ 229,500 |
500 μg | 約5 days | ¥ 486,500 |
生物学的情報 | Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is >20000 pmols/min/ug. |
説明 | Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | His |
Accession Number | O00748-1 |
別名 | carboxylesterase 2, CES2A1, CE-2, PCE-2, iCE |
Construction | The Human CES2 isoform 1 (O00748-1) (Met 1-Leu 559) was expressed, with a C-terminal polyhistidine tag. |
Protein Purity |
> 95 % as determined by SDS-PAGE
|
分子量 | 60.4 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM NaAc, 150 mM NaCl, 10% Glycerol, pH 5. 5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors. |
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Please read the User Guide of Recombinant Proteins for more specific information.
Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) carboxylesterase 2 CE2 CE 2 PCE 2 CES2A1 CE-2 PCE-2 iCE PCE2 recombinant recombinant-proteins proteins protein