CD161 Protein, Human, Recombinant (C-hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 42,500 |
50 μg | 約5 days | ¥ 125,000 |
500 μg | 約5 days | ¥ 436,000 |
1 mg | 約5 days | ¥ 682,000 |
説明 | CD161 Protein, Human, Recombinant (C-hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-hFc |
Accession Number | Q12918 |
別名 | Killer cell lectin-like receptor subfamily B member 1, NKR-P1A, Natural killer cell surface protein P1A, HNKR-P1a, C-type lectin domain family 5 member B, NKRP1A, KLRB1, CD161, CLEC5B |
Amino Acid | Gln67-Ser225 |
Construction | Gln67-Ser225 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. Greater than 81% as determined by SEC-HPLC. (QC verified) |
分子量 | 55-70 KDa, reducing conditions |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
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Please read the User Guide of Recombinant Proteins for more specific information.
CD161 Protein, Human, Recombinant (C-hFc) Killer cell lectin-like receptor subfamily B member 1 NKR-P1A Natural killer cell surface protein P1A CD 161 HNKR-P1a C-type lectin domain family 5 member B NKRP1A KLRB1 KLRB-1 CD-161 CD161 KLRB 1 CLEC5B recombinant recombinant-proteins proteins protein