CD299 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65 kDa and the accession number is Q9H2X3-1.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 在庫あり | ¥ 103,500 |
200 μg | 約5 days | ¥ 177,000 |
500 μg | 約5 days | ¥ 358,000 |
生物学的情報 | Testing in progress |
説明 | CD299 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65 kDa and the accession number is Q9H2X3-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | hFc |
Accession Number | Q9H2X3-1 |
別名 | LSIGN, CLEC4M, C-type lectin domain family 4 member M, MGC47866, MGC129964, CD209L, L-SIGN, DC-SIGN2, HP10347, CD299, DCSIGNR, DC-SIGNR |
Construction | The extracellular domain (Ser 78-Glu 399) of Human DC-SIGNR (NP_055072.3) was fused with the Fc region of Human IgG1 at the N-terminus. |
Protein Purity |
> 90 % as determined by SDS-PAGE
|
分子量 | 65 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | C-type lectin domain family 4, member M, also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77% amino acid identical to DC-SIGN, an HIV gp120-binding protein. Though the encoded gene located in the same chromosome, DC-SIGN is expressed solely on dendritic cells, while DC-SIGNR is predominantly found in liver sinusoidal endothelial cells and lymph node, as well as placental endothelium. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligomerization. DC-SIGNR is regarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediates the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGNR has been thought to play an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in the regional lymph nodes. It may affect susceptibility to HIV infection by a mechanism that is different in females and males. DC-SIGNR can bind to hepatitis C virus (HCV), and its polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy. |
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Please read the User Guide of Recombinant Proteins for more specific information.
CD299 Protein, Human, Recombinant (hFc) LSIGN MGC-47866 CLEC4M C-type lectin domain family 4 member M MGC47866 MGC129964 HP 10347 CD209L L-SIGN DC-SIGN2 MGC 129964 HP10347 MGC 47866 CD-299 MGC-129964 HP-10347 CD299 DCSIGNR CD 299 DC-SIGNR recombinant recombinant-proteins proteins protein