CD299 Protein, Human, Recombinant (His & Flag)
カタログ番号 TMPJ-01330
別名:
DC-SIGNR, L-SIGN, CD299, CD209L, LSIGN, C-type lectin domain family 4, member M, DCSIGNR, HP10347, CD209L1, DC-SIGN2, CLEC4M
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD299 Protein, Human, Recombinant (His & Flag)
| パッケージサイズ |
在庫状況 |
単価(税別) |
| 10 μg |
約5 days |
￥ 24,000 |
| 50 μg |
約5 days |
￥ 74,000 |
| 500 μg |
約5 days |
￥ 367,500 |
| 1 mg |
約5 days |
￥ 551,000 |
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生物学的特性に関する説明
Technical Params
Product Properties
| 説明 |
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. |
| Species |
Human
|
| Expression Host |
Human Cells
|
| Tag |
N-8His-Flag
|
| Accession Number |
Q9H2X3-8
|
| 別名 |
DC-SIGNR, L-SIGN, CD299, CD209L, LSIGN, C-type lectin domain family 4, member M, DCSIGNR, HP10347, CD209L1, DC-SIGN2, CLEC4M
|
| Amino Acid |
Ser73-Glu376
|
| Construction |
Recombinant Human C-type Lectin Domain Family 4 Member M is produced by our Mammalian expression system and the target gene encoding Ser73-Glu376 is expressed with a 8His, Flag tag at the N-terminus.
|
| Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
|
| 分子量 |
35-40 KDa, reducing conditions
|
| Endotoxin |
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
|
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
|
| Reconstitution |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|
| Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
|
| Shipping |
The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
|
| Research Background |
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation.
|
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技術サポート
Please read the User Guide of Recombinant Proteins for more specific information.
Keywords
CD299 Protein, Human, Recombinant (His & Flag)
CD-299
DC-SIGNR
HP 10347
L-SIGN
CD299
CD209L
LSIGN
C-type lectin domain family 4, member M
DCSIGNR
CD 299
HP10347
CD209L1
DC-SIGN2
CLEC4M
HP-10347
recombinant
recombinant-proteins
proteins
protein
