CISH Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9NSE2.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
20 μg | 約20 days | ¥ 45,500 |
100 μg | 約20 days | ¥ 89,500 |
1 mg | 約20 days | ¥ 385,500 |
説明 | CISH Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9NSE2. |
Species | Human |
Expression Host | E. coli |
Tag | N-GST |
Accession Number | Q9NSE2 |
別名 | Suppressor of cytokine signaling, Cytokine-inducible SH2-containing protein, SOCS, CIS-1, CIS, CISH, G18 |
Amino Acid | MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL |
Construction | 1-258 aa |
Protein Purity | > 90% as determined by SDS-PAGE. |
分子量 | 55.7 kDa (predicted) |
Formulation | Tris-based buffer, 50% glycerol |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
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Please read the User Guide of Recombinant Proteins for more specific information.
CISH Protein, Human, Recombinant (GST) Suppressor of cytokine signaling Cytokine-inducible SH2-containing protein SOCS CIS-1 CIS CISH G18 recombinant recombinant-proteins proteins protein