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Claudin-4 Protein-VLP, Human, Recombinant

カタログ番号 TMPK-00710
別名: Claudin4, CLDN4, Claudin-4, CPETR1, CPE-R, WBSCR8, CPE R

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

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Claudin-4 Protein-VLP, Human, Recombinant
パッケージサイズ 在庫状況 単価(税別)
100 μg 約5 days ¥ 372,000
500 μg 約5 days ¥ 1,496,500
1 mg 約5 days ¥ 2,495,000
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
Species Human
Expression Host HEK293 Cells
Accession Number O14493
別名 Claudin4, CLDN4, Claudin-4, CPETR1, CPE-R, WBSCR8, CPE R
Construction Met1-Val209
Protein Purity > 95% as determined by HPLC
分子量 23.31 kDa (predicted)
Endotoxin < 1 EU/μg by the LAL method.
Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4).Notice: If you need it for immunization, Do Not use any adjuvant.
Stability & Storage

It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

参考文献

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Keywords

Claudin-4 Protein-VLP, Human, Recombinant Claudin4 CLDN4 Claudin-4 WBSCR 8 CPETR-1 CPETR1 CPE-R WBSCR8 CPE R CLDN-4 CPETR 1 CLDN 4 WBSCR-8 recombinant recombinant-proteins proteins protein