Claudin-9 Protein, Human, Recombinant

Claudin-9 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.9 kDa and the accession number is O95484.

Claudin-9 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
20 μg	約5 days	￥ 229,500
100 μg	約5 days	￥ 484,500
500 μg	約5 days	￥ 1,710,000

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説明	Claudin-9 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.9 kDa and the accession number is O95484.

Species	Human
Expression Host	HEK293 Cells
Tag	Tag Free
Accession Number	O95484
Construction	Human CLDN9 (O95484) (Met1-Val217)
分子量	22.9 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 50 mM Hepes, 150 mM NaCl, 10% Trehalose, pH 7.2.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It forms heterotypic interactions with other claudins to create cation-selective channels in the kidney and may contribute to the maintenance of alveolar barrier function in the lung. Deficiency is shown to be associated with autosomal recessive deafness, DFNB116. CLDN9 expression has been shown to be upregulated in certain types of cancer, such as endometrial cancer and hepatocellular carcinoma, and its knockdown has been found to reduce cell proliferation and migration in vitro.

参考文献

1. Higashi, et al. Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Sci Rep, 202 2. Nakano, et al. A claudin-9-based ion permeability barrier is essential for hearing. PLoS Genet., 2009. 3. Zheng A, et al. Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus. J Virol. 2007. 4. Endo Y, et al. Claudin 9 is a novel prognostic biomarker for endometrial cancer. Int J Oncol. 2022. 5. Overgaard, et al. Roles for claudins in alveolar epithelial barrier function. Annals of the New York Academy of Sciences, 2012. 6. Liu, et al. Claudin-9 enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling. The Turkish Journal of Gastroenterology, 2019.

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Claudin-9 Protein, Human, Recombinant

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