CLEC10A Protein, Human, Recombinant (hFc)

CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.

CLEC10A Protein, Human, Recombinant (hFc)

パッケージサイズ	在庫状況	単価(税別)
50 μg	在庫あり	￥ 59,500
100 μg	約5 days	￥ 101,000
200 μg	約5 days	￥ 173,000
500 μg	約5 days	￥ 351,500

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生物学的情報	Testing in progress
説明	CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.

Species	Human
Expression Host	HEK293
Tag	hFc
Accession Number	Q8IUN9-2
別名	HML2, CD301, CLECSF13, HML, MGL, C-type lectin domain family 10, member A, CLECSF14
Construction	A DNA sequence encoding the human CLEC10A (Q8IUN9-2) (Gln61-His292) was expressed, with the fused Fc region of human IgG1 at the N-terminus.
Protein Purity	> 85 % as determined by SDS-PAGE
分子量	54.6 kDa (predicted)

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL)-10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria.

参考文献

1. Sabapathy K,et al.(2004) JNK2: a negative regulator of cellular proliferation. Cell Cycle. 3(12): 1520-3. 2. Tao J,et al.(2007) JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Eur J Immunol. 37(3): 818-29. 3. Shaw D,et al.(2008) The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. J Mol Biol. 383(4): 885-93. 4. Osto E,et al.(2008) c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. 118(20): 2073-80. 5. De Paiva CS,et al.(2009) Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 127(12): 1625-31. 6. Chen P,et al.(2010) Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One. 5(5): e10443.

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CLEC10A Protein, Human, Recombinant (hFc)

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