CRIP2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 22.6 kDa and the accession number is P52943.
説明 | CRIP2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 22.6 kDa and the accession number is P52943. |
Species | Human |
Expression Host | Baculovirus Insect Cells |
Tag | Tag Free |
Accession Number | P52943 |
別名 | CRP2, cysteine-rich protein 2, ESP1, CRIP |
Construction | The Human CRIP2 (P52943) (Met1-Pro208) was expressed and purified. |
Protein Purity | > 95 % as determined by SDS-PAGE |
分子量 | 22.6 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM Nacl, 10% glycerol, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. |
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Please read the User Guide of Recombinant Proteins for more specific information.
CRIP2 Protein, Human, Recombinant CRP2 ESP 1 CRP-2 cysteine-rich protein 2 ESP1 CRP 2 CRIP ESP-1 recombinant recombinant-proteins proteins protein