CSNK2A2 Protein, Human, Recombinant

CSNK2A2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.4 kDa and the accession number is P19784.

CSNK2A2 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
50 μg	在庫あり	￥ 114,500

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生物学的情報	Kinase activity untested
説明	CSNK2A2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.4 kDa and the accession number is P19784.

Species	Human
Expression Host	Baculovirus-Insect Cells
Tag	Tag Free
Accession Number	P19784
別名	CK2A2, CSNK2A1, casein kinase 2, alpha prime polypeptide, casein kinase 2, α prime polypeptide
Construction	A DNA sequence encoding the human CSNK2A2 (NP_001887.1) (Met 1-Arg 350) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	41.4 kDa (predicted)

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Supplied as sterile 20mM Tris, 500mM NaCl, 3mM DTT, pH 8.5. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Casein kinase II subunit alpha', also known as CSNK2A2 and CK2A2, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. CSNK2A2 is a tetramer composed of an alpha chain, an alpha' and two beta chains. It is also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Protein kinase casein kinase II (Ck2) is a cyclic-AMP and calcium-independent serine-threonine kinase that is composed of two catalytic subunits (alpha and alpha') and two regulatory beta-subunits. Ck2 is not a casein kinase in vivo, but over 1 substrates are known. The highly conserved amino acid sequences of its subunits and their broad expression suggest that Ck2 may have a fundamental role in cell function. Ck2 has been implicated in DNA replication, regulation of basal and inducible transcription, translation and control of metabolism. The Ck2alpha and Ck2alpha' isoforms (products of the genes Csnk2a1 and Csnk2a2, respectively) are highly homologous, the reason for their redundancy and evolutionary conservation is unknown. CSNK2A2 may be a candidate gene for these inherited syndromes.

参考文献

1. Xu X. et al., 1999, Nat Genet. 23 (1):118-21. 2. Aasland M. et al., 2000, Anim Genet. 31 (2):131-4. 3. Escalier D. et al., 2003, Mol Reprod Dev. 66 (2):190-201. 4. Ackermann K. et al., 2005, Mol Cell Biochem. 274 (1-2):91-101.

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CSNK2A2 Protein, Human, Recombinant

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