CXCL1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is A2RTH0.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
20 μg | 約5 days | ¥ 56,000 |
100 μg | 約5 days | ¥ 159,500 |
1 mg | 約5 days | ¥ 922,500 |
説明 | CXCL1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is A2RTH0. |
Species | Mouse |
Expression Host | E. coli |
Tag | Tag Free |
Accession Number | A2RTH0 |
別名 | Gro1, Scyb1, gro, KC, Fsp, N51, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, α), Mgsa |
Construction | Mouse Cxcl1 (NP_032202.1) (Arg20-Lys96) |
Protein Purity | > 90 % as determined by SDS-PAGE. |
分子量 | 8.3 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM Nacl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. |
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Please read the User Guide of Recombinant Proteins for more specific information.
CXCL1 Protein, Mouse, Recombinant Gro1 Scyb1 gro KC melanoma growth stimulating activity, alpha N-51 Fsp N51 chemokine (C-X-C motif) ligand 1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, α) N 51 Mgsa recombinant recombinant-proteins proteins protein